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    THE METAFOCUS® FORMULATION

    Learn about the science behind each ingredient

    TABLE OF NOOTROPICS

    NOOTROPIC COMPOUNDS

    Artichoke Extract

    FORSKOLIN

    ACETYL-L-CARNITINE

    SERINAID®

    COGNIZIN®

    GINKGO BILOBA

    DL-PHEnylalanine

    Alpha-Lipoic Acid

    BRAIN VITAMINS

    VITAMIN b5

    Vitamin B6

    Vitamin b9

    Vitamin B12

    Luteolin (Artichoke Extract)

    Serving Amount: 400 mg (5% cynarins) // 15mg (20% forskolii)

    Luteolin, a flavonoid found in artichoke extract, inhibits PDE4 in the brain, which increases cAMP. Forskolin also naturally increases cAMP levels, which is correlated with improved learning (focus), memory, and mood. The combination results in strengthening of neural synapses, otherwise known as long-term potentiation.[SOURCE]

    SerinAid® (Phosphatidylserine)

    Serving Amount: 100 mg 

    Phosphatidylserine is found in high amounts in the brain and supplementation has been researched to reduce cognitive decline and improve cognition, specifically long-term memory, as well as reducing symptoms of ADHD.[1] It has also been shown to reduce cortisol, a hormone correlated with anxiety. This therefore can support a reduction in intrusive thoughts resulting in improved mental clarity and increased attention.[2]

    ALCAR (Acetyl-L-Carnitine)

    Serving Amount: 400 mg

    ALCAR is the acetylated form of amino acid l-carnitine, which more easily crosses the blood-brain barrier, transporting fatty acids into the mitochondria for breakdown. Supplementation is shown to improve mitochondrial function and energy metabolism, as well as increase levels of noradrenaline, the neurotransmitter associated with focus and alertness. It is also shown to be effective in combatting depression, anxiety, and brain fog.

    • Luteolin + Forskolin
    • ALCAR
    • ALA
    • SerinAid®
    • Ginkgo
    • Phenylalanine
    • Cognizin®

    Luteolin (Artichoke Extract) // Forskolin

    Serving Amount: 400 mg (5% cynarins) // 15mg (20% forskolii)

    Luteolin, a flavonoid found in artichoke extract, inhibits PDE4 in the brain, which increases cAMP. Forskolin also naturally increases cAMP levels, which is correlated with improved learning (focus), memory, and mood. The combination results in strengthening of neural synapses, otherwise known as long-term potentiation.[SOURCE]

    CLINICALLY-BACKED RESEARCH

    Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice

    Journal of Nutrition

    Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro.

    Free Radical Research

    Forskolin and derivatives as tools for studying the role of cAMP. 

    Pharmazie

    Total of 3,691 studies on Luteolin & 19,035 studies on Forskolin

    EVIDENCE-BASED RESEARCH

    • Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant [6]
    • Assessment of pharmacokinetic interaction between piracetam and L-carnitine in healthy subjects [7]
    • Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress [8]
    • Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice [9]
    • A review of current evidence for acetyl-l-carnitine in the treatment of depression [10]
    • Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine [11]
    • Upregulation of mGlu2 receptors via NF-κB p65 acetylation is involved in the Proneurogenic and antidepressant effects of acetyl-L-carnitine [12]


    ALA (Alpha-Lipoic Acid)

    Serving Amount: 100 mg

    Alpha-lipoic acid (ALA) is a mitochondrial compound involved in energy metabolism and production of the cognition neurotransmitter, acetylcholine. It has a related mechanism of action to ALCAR and has been shown to boost cellular energy and protect brain neurons. Supplementation may also aid in preventing cognitive and neurological diseases like Alzheimer’s, Parkinson’s and depression. 

    EVIDENCE-BASED RESEARCH

    • The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview.
    • The Effect of Alpha-Lipoic Acid on Mitochondrial Superoxide and Glucocorticoid-Induced Hypertension


    CASE STUDY: THE EFFECTS OF PHOSPHATIDYLSERINE ON GOLF PERFORMANCE

    Phosphatidylserine supplementation significantly improved the ball flight accuracy of golfers as compared to the group that was given the placebo supplements.

    Phosphatidylserine supplementation improved perceived stress levels during tee-off on a driving range, whereas perceived stress levels remained unchanged in the placebo group.

    Ginkgo Biloba Extract

    Serving Amount: 80 mg (24% ginkgo flavone glycosides, 6% total terpene lactones)

    Ginkgo Biloba is an antioxidant-rich herb that has been shown to improve brain health and cognitive functions, specifically attention and memory recall. Long-term supplementation has also been shown to slow age-related intellectual decline and as a vasodilator, it increases cerebral blood flow. In addition, Ginkgo is used to treat conditions such as altitude sickness, dementia, and tinnitus.

    EVIDENCE-BASED RESEARCH

    • Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy
    • A double-blind, randomized clinical trial of dietary supplementation on cognitive and immune functioning in healthy older adults
    • Is Ginkgo biloba a cognitive enhancer in healthy individuals? A meta-analysis.
    • Cognitive effects of a Ginkgo biloba/vinpocetine compound in normal adults: systematic assessment of perception, attention and memory.
    • Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. 


    DL-Phenylalanine

    Serving Amount: 250 mg

    Phenylalanine is an amino acid that is an essential building block for the neurotransmitter dopamine. Higher dopamine levels in the brain is correlated with improved attention span, follow-through, and motivation. Supplementation has also been shown to improve mood and reduce stress.

    EVIDENCE-BASED RESEARCH

    • Dietary tyrosine/phenylalanine depletion effects on behavioral and brain signatures of human motivational processing
    • Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain.


    Cognizin® Citicoline

    Serving Amount: 100 mg

    Alpha-GPC is natural choline compound found in the brain. Choline, a nutrient found in common foods such as fish and eggs, is essential for the functioning of the acetylcholine neurotransmitter, which helps nerves to communicate, increase attention-span & memory capacity, and prevent cognitive decline.

    EVIDENCE-BASED RESEARCH

    • Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults
    • Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial