Heightened concentration and focus†
Ease of getting into flow state†
Improved mitochondrial health and energy production†
Improved mental processing speed and accuracy†
Reduction in intrusive thoughts and brain fog†
FEATURED IN
Unlock Your Mind's Full Potential
INTENSE FOCUS
LASER-SHARP MEMORY
UNSTOPPABLE DRIVE
The metaBRAIN® box contains three nootropic supplements each with their own unique ingredient formulations, known as nootropic stacks.
Each stack is centered around a fundamental cognitive pillar: focus for metaFOCUS®, memory for metaMEMORY®, and motivation for metaDRIVE®.
The three stacks are formulated with a collective total of 31 powerhouse nootropic ingredients—all in their clinically recommended dosages.
Tools To Augment
The Human Mind
Formulated with the help of medical professionals to ensure that they were safe and effective synergistically.
We only used ingredients backed by an extensive amount of published research to target all key brain pathways, producing the maximum cognitive benefits.
After years of research, trials, and numerous iterations, we are now able to provide you the tools to augment the human mind.†
An upgrade to your brain operating system.†
Fully customizable, you can take the supplement(s) based on the mental areas you need optimized. Ultimately, integrating all three stacks provides the most profound enhancement to your brain.†
Experience
metaBRAIN®
Memory Retention
Attention-Span & Focus
Planning & Reasoning
Mental Clarity
Motivation & Productivity
EnhanceD Creativity
Improved Brain Health
Mood & Stress-Relief
Verbal Fluency
Energy & Alertness
Three is Better Than One
Reach Your Peak Mental Performance†
METAFOCUS®
Flow State • Processing Speed • Mental Clarity†
BENEFITS
COGNITIVE RATINGS
FORMULATION
NOOTROPIC COMPOUNDS
ALCAR
400 mg
Luteolin
400 mg
Phenylalanine
250 mg
SerinAid®
100 mg
Cognizin®
100 mg
ALA
100 mg
Ginkgo Biloba
70 mg
Forskolin
15 mg
BRAIN VITAMINS
Vitamin B5
20 mg
Vitamin B6
5 mg
Vitamin B9
1 mg
Vitamin B12
600 mcg
METAMEMORY®
MEMORY • BRAIN HEALTh • Verbal Fluency†
BENEFITS
Improved memory retention and recall†
Enhanced verbal fluency and word recall†
Heightened mental clarity and reduced brain-fog†
Improved brain health†
Reduced oxidative stress in the brain†
COGNITIVE RATINGS
FORMULATION
NOOTROPIC COMPOUNDS
Lion's Mane
400 mg
Uridine
300 mg
Bacopa
250 mg
Alpha-GPC
100 mg
Pine Bark
100 mg
DHA
80 mg
BioPerine®
10 mg
Huperzine-A
40 mcg
BRAIN VITAMINS
Vitamin B5
50 mg
Vitamin B9
1 mg
Vitamin B12
100 mcg
Vitamin C
45 mg
METADRIVE®
MOTIVATION • Smooth ENERGY • STRESS Resilience†
BENEFITS
Focused energy without the jitters or crash†
Increased motivation and productivity levels†
Improved resilience to stress†
Heightened alertness and reduced fatigue†
Enhanced creativity from increase in alpha brain waves†
COGNITIVE RATINGS
FORMULATION
NOOTROPIC COMPOUNDS
Rhodiola
300 mg
NA-Tyrosine
250 mg
Sulbutiamine
200 mg
L-Theanine
200 mg
Ashwagandha
180 mg
Caffeine
100 mg
EGCG
100 mg
L-Dopa
80 mg
BRAIN VITAMINS
Niacin
40 mg
Vitamin B6
10 mg
Vitamin B12
200 mcg
Vitamin D3
1000 IU
METABRAIN®
INTENSE FOCUS • LASER-SHarp Memory • Unstoppable Drive†
INTENSE FOCUS
LASER-SHarp Memory
Unstoppable Drive†
Synergy For Total mental optimization
Each stack in metaBRAIN® is effective on its own. But since the formulas work through mechanisms that are interconnected, you will notice synergy and efficacy when taking multiple stacks at once.
Supplementing with all three together provides the most comprehensive enhancement to your brain.†
More than just a Brain supplement
Each metaBRAIN® box includes "Upgrade Your Brain, Upgrade Your Life", a 16-page booklet detailing how you can get the most out of metaBRAIN®.
The guide also introduces the branches for an upgraded life, which includes 16 foundational habits you can practice to reach your peak human potential—for both beginner and more experienced biohackers.
UPGRADE YOUR BRAIN. UPGRADE YOUR LIFE.
Peak performers. Peak results.
Peak performers.
Peak results.
"As CEO of an ad agency, I have to lead by example. metaBRAIN keeps me at the top of my game and helps me scale my clients."
Alexandre Bocquet
Founder & Ceo, Ad Agency
"metaBRAIN helps me with my creative process at work and also aids in maintaining my focus while I'm out surfing."
Mackenzie Anderson
Creative Director
"metaBRAIN really helped me to lock in and get into flow state. The whole day I basically had smooth energy and focus. Replaced all my old supplements."
Acer Chang
Entrepreneur & Athlete
THE METABRAIN® DIFFERENCE
THE METABRAIN®
DIFFERENCE
There's a ton of nootropic supplements out there. But most of them have minimally dosed ingredients, toxic fillers, cookie-cutter formulations, and/or no research to back them. Here's the metaBRAIN® difference:
Full Formulation & Company Transparency
We want you to know what you are putting in your body so we guarantee 100% transparency. This includes every aspect of our formulations such as disclosing all ingredient amounts, sourcing, and 3rd party testing.
Rest assured you're getting only the highest quality nootropic ingredients when taking metaBRAIN®.
Customizable & Personalized protocol
metaBRAIN® is customizable and each formula is effective on their own, with clinically-backed ingredients and proven synergies. In each box bundle, we provide you a comprehensive supplementation protocol based on your body-weight and cognitive requirements.
Whether you need to optimize your focus, memory, drive, or all three, metaBRAIN® contains nootropics that do it all. Ultimately, supplementing with all three stacks together provides the most comprehensive enhancement to your mind.
Clinically recommended Dosages
Nootropics often have "proprietary blends" with ingredient dosages far below clinically recommended amounts. These blends are often packed into 1-3 capsules which do not have enough space to contain all the ingredients in their recommended amounts.
That's why we designed metaBRAIN® with three stacks, so that all ingredients within each formulation have clinically recommended dosages for full efficacy.
Formulations fully Backed by Science
The collective metaBRAIN® formulation was created through extensive research and development by our team of biohackers, along with the help of doctors and naturopaths. All of our claims are backed by published research which can be found in the "references" section on the bottom of each product page.
We will also be working with Cambridge Brain Sciences to conduct an observational study measuring the cognitive improvement of volunteers over a 6-week period. Details coming soon.
60-Day Money-Back guarantee
We're confident in the efficacy of metaBRAIN and its three stacks, so we have a 60-day money-back guarantee policy with no returns needed. All we ask is that you give it at least 2 weeks of consistent use for the stack(s) to experience the full effects. To learn more go to our return policy page.
OUTSOURCE YOUR COGNITIVE ENHANCEMENT
COST-EFFECTIVE MENTAL OPTIMIZATION
METAFOCUS®
METAMEMORY®
METADRIVE®
METABRAIN®
MARKET PRICE
IF BOUGHT INDIVIDUALLY*
METAFOCUS®
METAMEMORY®
METADRIVE®
METABRAIN®
META
FOCUS
META
MEMORY
META
DRIVE
META
BRAIN
$205.50
$243.89
$182.64
$562.05
OUR PRICE
PER MONTH
META
FOCUS
META
MEMORY
META
DRIVE
META
BRAIN
METAFOCUS®
METAMEMORY®
METADRIVE®
METABRAIN®
$36.42
$35.40
$36.84
$93.37
* These prices are based on the prices of the top supplements sold on Amazon with similar quality to the ingredients in each of the metaBRAIN® formulas.
Who really wants to take 31+ different supplements at the expensive price of $562 to enhance your brain function? We make it easy for you with a cost-effective (and time-saving) solution to get mentally optimized.
You also have peace of mind knowing that all the nootropic ingredients within the metaBRAIN® supplements are of the highest quality, backed by extensive research.
31 powerhouse Ingredients.
the convenience of 3 supplements.
"Man will not wait passively for millions of years before evolution offers him a better brain."
CORNELIU E GIURGEA
"THE FATHER OF NOOTROPICS"
Dr. Helen Okoye M.D.
NATIONAL INSTITUTES OF HEALTH (NIH)
CLINICAL AND RESEARCH FELLOW
The nootropics supplements industry is on the rise. With companies selling brain-enhancement pills sprouting up from all over the country, it’s hard to distinguish which are actually safe and effective. In all my years working as a medical professional, I’ve seen many nootropic products. However, Nuoptimal’s metaBRAIN stands out.
The clinically-backed supplement holistically covers all components of cognitive enhancement. Each supplement in the metaBRAIN box is formulated to be safe, affordable, and most importantly, effective.
Dr. Helen Okoye M.D.
NATIONAL INSTITUTES OF HEALTH (NIH)
CLINICAL AND RESEARCH FELLOW
Customer Reviews
4.8 Based on 79 Reviews
Write a Review Filter Reviews:
RT
07/26/2023
Ronnie T.
United StatesGreat
I have been using nuoptimal for about a year it is a great product I will keep using it
AT
05/07/2023
Alexander T.
United StatesBest i've had yet
It was great to have for work, love no caffeine fix.
MT
10/22/2022
Mitchell T.
United StatesGreat product
I only use these sparingly as needed, but find great benefit in using them! My clearness of head and focus and clarity of mind are phenomenal when I use these.
JH
10/02/2022
Jessica H.
United StatesCANCEL!!!
Please cancel my auto ship. I cannot get you to stop sending and charging me. I want refunded for the last 9 bottles you’ve sent me. I’ve emailed which is the only way I can find to contact you. PLEASE RESPOND TO MY EMAILS!
CB
05/27/2022
Corey B.
United StatesGreat Product
MetaBrain works, it's definitely a quality product that I can really feel is helping my brain in various ways.
Patents & Trademarks
Cognizin® is a registered trademark of KYOWA HAKKO BIO CO., LTD.
SerinAid® is a registered trademark of Chemi Nutra. SerinAid is protected under U.S. patent numbers 5,700,668, 6,492,146, 6,645,742, 6,673,378, and 8,124,594.
BioPerine® is a registered trademark of Sabinsa Corporation.
Memory Retention
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- Ratto, Daniela et al. “Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging.” Nutrients vol. 11,4 715. 27 Mar. 2019, doi:10.3390/nu11040715
- Kumar, Hemant et al. “Promising therapeutics with natural bioactive compounds for improving learning and memory--a review of randomized trials.” Molecules (Basel, Switzerland) vol. 17,9 10503-39. 3 Sep. 2012, doi:10.3390/molecules170910503
- Brandalise, Federico et al. “Dietary Supplementation of Hericium erinaceusIncreases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice.” Evidence-based complementary and alternative medicine : eCAM vol. 2017 (2017): 3864340. doi:10.1155/2017/3864340
- Micheau J, Durkin TP, Destrade C, Rolland Y, Jaffard R. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacol Biochem Behav. 1985 Aug;23(2):195-8. PubMed PMID: 4059305.
- Lynch MA. Long-term potentiation and memory. Physiol Rev. 2004 Jan;84(1):87-136. Review. PubMed PMID: 14715912.
Attention-Span & Focus
- Ahn, James et al. “Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy.” Neural plasticity vol. 2016 (2016): 1320423. doi:10.1155/2016/1320423
- McGlade E, Agoston AM, DiMuzio J, Kizaki M, Nakazaki E, Kamiya T, Yurgelun-Todd D. The Effect of Choline Supplementation on Motor Speed and Attention in Adolescent Males. J Atten Disord. 2019 Jan;23(2):121-134. doi: 10.1177/1087054715593633. Epub 2015 Jul 15. PubMed PMID: 26179181.
- Food and Nutrition Sciences et al. "Improved Attentional Performance Following Choline Administration in Healthy Adult Women" 2012, 3, 769-773. doi:10.4236/fns.2012.36103 Published Online June 2012
- Kahathuduwa, Chanaka et al. “L-theanine and Caffeine Improve Sustained Attention, Impulsivity and Cognition in Children with Attention Deficit Hyperactivity Disorders by Decreasing Mind Wandering (OR29-04-19).” Current Developments in Nutrition vol. 3,Suppl 1 nzz031.OR29-04-19. 13 Jun. 2019, doi:10.1093/cdn/nzz031.OR29-04-19
- Bloch, Michael H, and Jilian Mulqueen. “Nutritional supplements for the treatment of ADHD.” Child and adolescent psychiatric clinics of North America vol. 23,4 (2014): 883-97. doi:10.1016/j.chc.2014.05.002
Planning & Reasoning
- Gomez-Ramirez M, Kelly SP, Montesi JL, Foxe JJ. The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr. 2009 Jun;22(1):44-51. doi: 10.1007/s10548-008-0068-z. Epub 2008 Oct 9. PubMed PMID: 18841456.
- Kurniawan, Irma Triasih et al. “effort-based decision making.” Frontiers in neuroscience vol. 5 81. 21 Jun. 2011, doi:10.3389/fnins.2011.00081
- Picciotto, Marina R et al. “Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior.” Neuron vol. 76,1 (2012): 116-29. doi:10.1016/j.neuron.2012.08.036
Mental Clarity
- Dietz C, Dekker M. Effect of Green Tea Phytochemicals on Mood and Cognition.Curr Pharm Des. 2017;23(19):2876-2905. doi: 10.2174/1381612823666170105151800.Review. PubMed PMID: 28056735.
- Gestuvo, Mk, and Ww Hung. “Common dietary supplements for cognitive health.” Aging health vol. 8,1 (2012): 89-97. doi:10.2217/AHE.11.92
- Theoharides, Theoharis C et al. “Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin.” Frontiers in neuroscience vol. 9 225. 3 Jul. 2015, doi:10.3389/fnins.2015.00225
Motivation & Productivity
- Westbrook, Andrew, and Todd S Braver. “Does Double Duty in Motivating Cognitive Effort.” Neuron vol. 89,4 (2016): 695-710. doi:10.1016/j.neuron.2015.12.029
- Bloemendaal, Mirjam et al. “Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older Adults.” eNeuro vol. 5,2 ENEURO.0035-17.2018. 30 Apr. 2018, doi:10.1523/ENEURO.0035-17.2018
- Trovero F, Gobbi M, Weil-Fuggaza J, Besson MJ, Brochet D, Pirot S. Evidence for a modulatory effect of sulbutiamine on glutamatergic cortical transmissions in the rat brain. Neurosci Lett. 2000 Sep 29;292(1):49-53. PubMed PMID: 10996447.
- Veĭn AM, Fedotova AV, Gordeev SA. [Use of enerion in psychovegetative syndrome with pronounced asthenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2003;103(10):36-9. Russian. PubMed PMID: 14628585.
Enhanced Creativity
- Gomez-Ramirez M, Kelly SP, Montesi JL, Foxe JJ. The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr. 2009 Jun;22(1):44-51. doi: 10.1007/s10548-008-0068-z. Epub 2008 Oct 9. PubMed PMID: 18841456.
- Fink, Andreas, and Mathias Benedek. “EEG alpha power and creative ideation.” Neuroscience and biobehavioral reviews vol. 44,100 (2014): 111-23. doi:10.1016/j.neubiorev.2012.12.002
- Zabelina, Darya L et al. “and the Creative Mind: Individual Differences in Creativity Are Predicted by Interactions between Genes DAT and COMT.” PloS one vol. 11,1 e0146768. 19 Jan. 2016, doi:10.1371/journal.pone.0146768
Improved Brain Health
- Ratto, Daniela et al. “Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging.” Nutrients vol. 11,4 715. 27 Mar. 2019, doi:10.3390/nu11040715
- Li, I-Chen et al. “Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines.” Behavioural neurology vol. 2018 5802634. 21 May. 2018, doi:10.1155/2018/5802634
- Iravani, S, and B Zolfaghari. “Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract.” Research in pharmaceutical sciences vol. 6,1 (2011): 1-11.
- Wurtman, Richard J. “A nutrient combination that can affect synapse formation.” Nutrients vol. 6,4 1701-10. 23 Apr. 2014, doi:10.3390/nu6041701
- Kwon, Hyun Jung et al. “Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus.” Laboratory animal research vol. 34,4 (2018): 239-247. doi:10.5625/lar.2018.34.4.239
- Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA. Choline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008 Nov;21(10):1066-75. doi: 10.1002/nbm.1281. PubMed PMID: 18816480.
Mood & Stress-Relief
- Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations. Washington (DC): National Academies Press (US); 1994. 20, Effects of Caffeine on Cognitive Performance, Mood, and Alertness in Sleep-Deprived Humans.
- Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats Carlezon, William A. et al. Biological Psychiatry, Volume 57, Issue 4, 343 - 350
- White, David J et al. “Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.” Nutrients vol. 8,1 53. 19 Jan. 2016, doi:10.3390/nu8010053
- Chandrasekhar, K et al. “A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.” Indian journal of psychological medicine vol. 34,3 (2012): 255-62. doi:10.4103/0253-7176.106022
- Pratte, Morgan A et al. “An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera).” Journal of alternative and complementary medicine (New York, N.Y.) vol. 20,12 (2014): 901-8. doi:10.1089/acm.2014.0177
- Yoto, Ai et al. “Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses.” Journal of physiological anthropology vol. 31,1 28. 29 Oct. 2012, doi:10.1186/1880-6805-31-28
- Jongkees BJ, Hommel B, Kühn S, Colzato LS. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review. J Psychiatr Res. 2015 Nov;70:50-7. doi: 10.1016/j.jpsychires.2015.08.014. Epub 2015 Aug 25. Review. PubMed PMID: 26424423.
Verbal Fluency
- Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015 Jun;31(6):781-6. doi: 10.1016/j.nut.2014.10.014. Epub 2014 Nov 4. Review. PubMed PMID: 25933483.
- Peter, Jessica et al. “Contribution of the Cholinergic System to Verbal Memory Performance in Mild Cognitive Impairment.” Journal of Alzheimer's disease : JAD vol. 53,3 (2016): 991-1001. doi:10.3233/JAD-160273
- Hasselmo, Michael E. “The role of acetylcholine in learning and memory.” Current opinion in neurobiology vol. 16,6 (2006): 710-5. doi:10.1016/j.conb.2006.09.002
Energy & Alertness
- Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations. Washington (DC): National Academies Press (US); 1994. 20, Effects of Caffeine on Cognitive Performance, Mood, and Alertness in Sleep-Deprived Humans.
- Sevim S, Kaleağası H, Taşdelen B. Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis. Mult Scler Relat Disord. 2017 Aug;16:40-43. doi: 10.1016/j.msard.2017.05.010. Epub 2017 Jun 9. PubMed PMID: 28755683.
- Tiev KP, Cabane J, Imbert JC. [Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo]. La Revue de Medecine Interne. 1999 Oct;20(10):912-918. DOI: 10.1016/s0248-8663(00)80096-x.
- Harpaz E, Tamir S, Weinstein A, Weinstein Y. The effect of caffeine on energy balance. J Basic Clin Physiol Pharmacol. 2017 Jan 1;28(1):1-10. doi: 10.1515/jbcpp-2016-0090. Review. PubMed PMID: 27824614.