Ginkgo biloba has been shown to increase cerebral blood flow, which is linked to activating flow state.[10]
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FULL INGREDIENT TRANSPARENCY
Eradicate Brain Fog.
Improve Concentration.
Brain fog is a common issue that people face daily. It is characterized by confusion, forgetfulness, and a lack of focus and clarity. By eradicating brain fog you’ll be able to maximize your daily work output and utilize your time more efficiently.
THE NEUROTRANSMITTER OF LEARNING
One of the primary mechanisms our formula works is by modulating acetylcholine, the "learning neurotransmitter".
This neurotransmitter plays a key role in optimal cognitive functions specifically through improving attention-span, memory, and quick-thinking.[14]
Lightning-Fast Mental Accuracy & Speed
To optimize acetycholine levels, we've included ALCAR and Cognizin®.
ALCAR is a form of amino acid L-Carnitine which crosses the blood-brain barrier more easily and has been shown to boost memory, alertness, and fluid thought.[15]
Cognizin® boosts acetylcholine levels in the brain. Clinical trials have shown that Cognizin® improved focus, accuracy, specifically increasing the formation of brain membranes by 26% and brain energy utilization by 13.6%.[16] [17]
metaFOCUS can help you enter the elusive flow state while eradicating brain fog.
So what is flow state?
flow state noun
/ flō ˈstāt /
the brain’s optimal state of consciousness where an individual utilizes their skills to the utmost. In this state, individuals feel, perform, and focus at their best.
Key Compounds FOR Flow State
Gingko Biloba
Phosphatidylserine
Phosphatidylserine has been shown to reduce cortisol, the "stress hormone", eradicating the stress that can hinder you in achieving flow state.[11]
Dl-Phenylalanine
In flow, the brain releases key neurotransmitters which Phenylalanine are the building blocks for.
DL-Phenylalanine can also help reduce brain fog due to how it binds with glutamate AMPA receptors, improving communication between brain synapses.[12]
Acetyl-L-Carnitine
ALCAR has been shown to induce mental clarity and combat mental fatigue, supporting you in reaching flow.[13]
In a decade-long study conducted by McKinsey and Co. top executives found themselves 500% more productive when in flow.
FEATURED IN
Relieve Stress and Boost Productivity
Don’t let stress interrupt your workflow. metaFOCUS can help nullify mental stressors effectively and boost your productivity.
That’s why we’ve incorporated SerinAid® into our formula, a trademarked version of PhosphatidylSerine (PS), standardized to 70%. PS is a nootropic that plays a critical role in improving mental performance and reducing the body’s physiological response to stress by lowering cortisol levels.[18]
DL-Phenylalanine has been shown to enhance overall mood and improve ability to handle stress.[19]
Reducing Stress SUPPORTS YOU IN Attaining zen-like concentratioN
Clinical Trial
PHOSPHATIDYLSERINE VS PLACEBO
Golfers taking Phosphatidylserine noticed an increase in golfing accuracy and a decrease in perceived stress levels on the driving range compared to the placebo group.[20]
Increased Ball Flight Accuracy
PhosphatidylSerine supplementation significantly improved the ball flight accuracy of golfers as compared to the group that was given the placebo supplements.
Reduced Stress Levels During Tee-Off
PhosphatidylSerine supplementation improved perceived stress levels during tee-off on a driving range, while perceived stress levels remained unchanged in the placebo group.
FORMULATED WITH INGREDIENTS BACKED BY CLINICAL RESEARCH
8 NOOTROPIC COMPOUNDS
Artichoke Extract
400 mg (5% cynarins)
Luteolin, found in artichoke extract inhibits PDE4, which increases cAMP. Higher cAMP levels is correlated with improving learning, memory, and mood.[1]
FORSKOLIN
15 mg (20% forskolii)
Forskolin naturally increases cAMP levels synergizing with luteolin to strengthen neural synapses, also known as long-term potentiation improving cognitive function over time.[2]
Acetyl-l-carnitine
400 mg
ALCAR improves mitochondrial function and increase levels of noradrenaline, associated with focus and alertness. It has also been shown to be effective in reducing brain fog.[3]
SERinaid®
100 mg (PhosphatidylSerine)
PhosphatidylSerine has been shown to improve memory & increase concentration. It can also lower cortisol, reducing stress & intrusive thoughts.[4]
Artichoke Extract
400 mg (5% cynarins)
Luteolin, found in artichoke extract inhibits PDE4, which increases cAMP. Higher cAMP levels is correlated with improving learning, memory, and mood.[1]
FORSKOLIN
15 mg (20% forskolii)
Forskolin naturally increases cAMP levels synergizing with luteolin to strengthen neural synapses, also known as long-term potentiation improving cognition over time.[2]
Acetyl-l-carnitine
400 mg
ALCAR improves mitochondrial function and increase levels of noradrenaline, associated with focus and alertness. It has also been shown to be effective in reducing brain fog.[3]
SERinaid®
100 mg (PhosphatidylSerine)
PhosphatidylSerine has been shown to reduce cognitive decline, improve memory & reduce symptoms of ADHD. It can also lower cortisol, reducing anxiety & intrusive thoughts.[4]
GinkGO BILOBA
70 mg (24% glycosides)
Ginkgo Biloba is an antioxidant-rich herb that has been shown to increase cerebral blood flow, improving brain health and cognition, specifically attention and memory recall.[5]
DL-PHENYLALANINE
250 mg
Phenylalanine is an amino acid that is a building block for the neurotransmitter dopamine. Higher dopamine levels in the brain is correlated with improved attention-span, mood, and motivation.[6]
Cognizin®
100 mg
Citicoline modulates levels of the acetylcholine neurotransmitter, which helps nerves to communicate, increase attention-span, memory capacity, and prevent cognitive decline.[7]
Alpha-Lipoic Acid
100 mg (thiotic acid)
ALA is a mitochondrial compound that works similarly to ALCAR involved in energy metabolism and the production of acetylcholine. It has been shown to boost cellular energy and protect brain neurons.[8]
GinkGO BILOBA
70 mg (24% glycosides)
Ginkgo Biloba is an antioxidant-rich herb that has been shown to increase cerebral blood flow, improving brain health, attention-span, and memory recall.[5]
DL-PHENYLALANINE
250 mg
Phenylalanine is an amino acid that has been shown to produce improved attention-span, mood, and motivation.[6]
Cognizin®
100 mg
Cognizin® modulates levels of the acetylcholine neurotransmitter, which helps nerves to communicate, increase attention-span, and memory capacity.[7]
Alpha-Lipoic Acid
100 mg (thiotic acid)
ALA is a mitochondrial compound that works similarly to ALCAR involved in energy metabolism and the production of acetylcholine.[8]
4 BRAIN VITAMINS
Vitamin b5
20 mg (pantothenic acid)
Essential for converting cholinergic nootropics into acetylcholine, the neurotransmitter responsible for focus, memory, and learning.[9]
Vitamin b6
5 mg (pyridoxal 5’-phosphate)
An essential vitamin which is required for the biosynthesis of several key neurotransmitters. We use P5P, one of the most bioactive forms of B6.[9]
Vitamin b9
1 mg (folic acid)
B9 is required for the synthesis of key neurotransmitters such as serotonin, playing an integral role in improving mood and cognitive function.[9]
Vitamin b12
600 mcg (methylcobalamin)
B12 is crucial for the synthesis of key neurotransmitters. Optimizing these neurotransmitters improve our mood, energy, and stress levels.[9]
THE Powerhouse of our Cells
Optimal mitochondria for an optimal you
Mitochondria are the “powerhouses of our cells". They are responsible for every action in your body and brain. By improving the function of our mitochondria, the more energy they provide, which means a more optimal you.
Boost Mitochondrial Function
ALCAR transports fatty acids into mitochondria where they are burned for fuel. The compound has been shown improve mood, mental endurance, and other cognitive functions.[21]
The combination of Acetyl-L-Carnitine (ALCAR) and Alpha-lipoic Acid (ALA) both work to boost mitochondrial function.[22]
Increase Cellular Energy Production
ALA is a cofactor for mitochondrial enzymes involved in cellular energy production, which is responsible for every single action that happens in your brain and body. It's made inside the mitochondria where it helps enzymes turn nutrients into energy. Cellular energy is critical for muscle movement, producing new cells (neurogenesis), and thinking.[23]
Strengthen Synapses Between Neurons
The combination of Luteolin and Forskolin work through a process that strengthens neural synapses, called long-term potentiation. This works through an inhibition of the enzyme PDE4, which breaks down cAMP—messenger systems that relay signals in the brain. Luteolin, one of the compounds found in artichoke extract, is a proven PDE4 inhibitor. Forskolin (the compound extracted from the Coleus Forskohlii plant) has been shown to increase cAMP levels.[24]
Higher cAMP levels results in better brain function in areas such as focus, learning, and memory.[25]
The formula works to improve mitochondrial function, increase levels of key neurotransmitters, and strengthen neural synapses—to improve your focus, memory and overall brain function.†
Unlock Your Mind's Full Potential
metaFOCUS® is just one component of the optimal mental performance equation. Tap into your true potential and comprehensively upgrade your brain with metaBRAIN®, a three-supplement box designed for peak mental performance.
Formulated with a collective 31 nootropic ingredients, the three supplements in the metaBRAIN® box complement each other, sharpening focus, enhancing memory recollection, and igniting drive.†
Experience Intense Focus, Laser-Sharp Memory & Unstoppable Drive.†
Upgrade Your Brain, Upgrade Your Life.
The metaBRAIN® box includes "Upgrade Your Brain, Upgrade Your Life", a 16-page booklet that contains a comprehensive supplementation protocol based on your body-weight and cognitive requirements.
The booklet also introduces the branches for an upgraded life, which includes 16 foundational habits you can practice to reach your peak human potential—for both beginner and more experienced biohackers.
METABRAIN® IS Designed to Optimize All Areas Of Brain Function†
Memory Retention
Attention-Span & Focus
Planning & Reasoning
Mental Clarity
Motivation & Productivity
EnhanceD Creativity
Improved Brain Health
Mood & Stress-Relief
Verbal Fluency
Energy & Alertness
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Patents & Trademarks
Cognizin® is a registered trademark of KYOWA HAKKO BIO CO., LTD.
SerinAid® is a registered trademark of Chemi Nutra. SerinAid is protected under U.S. patent numbers 5,700,668, 6,492,146, 6,645,742, 6,673,378, and 8,124,594.
References
[1] Abel, Ted, and Peter V Nguyen. “Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.” Progress in brain researchvol. 169 (2008): 97-115. doi:10.1016/S0079-6123(07)00006-4
[2] Lepski, Guilherme et al. “cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.” Frontiers in cellular neuroscience vol. 7 155. 19 Sep. 2013, doi:10.3389/fncel.2013.00155
[3] Loots DT, Mienie LJ, Bergh JJ, Van der Schyf CJ. Acetyl-L-carnitine preventstotal body hydroxyl free radical and uric acid production induced by1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat. Life Sci. 2004Jul 23;75(10):1243-53. PubMed PMID: 15219812.
[4] Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015Jun;31(6):781-6. doi: 10.1016/j.nut.2014.10.014. Epub 2014 Nov 4. Review. PubMedPMID: 25933483.
[5] Mashayekh, Ameneh et al. “Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study.” Neuroradiology vol. 53,3 (2011): 185-91. doi:10.1007/s00234-010-0790-6
[6] Lou HC. Dopamine precursors and brain function in phenylalanine hydroxylasedeficiency. Acta Paediatr Suppl. 1994 Dec;407:86-8. Review. PubMed PMID: 7766968.
[7] Fioravanti, Mario, and Ann E Buckley. “Citicoline (Cognizin) in the treatment of cognitive impairment.” Clinical interventions in aging vol. 1,3 (2006): 247-51. doi:10.2147/ciia.2006.1.3.247
[8] Packer, Lester, and Enrique Cadenas. “Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling.” Journal of clinical biochemistry and nutrition vol. 48,1 (2011): 26-32. doi:10.3164/jcbn.11-005FR
[9] Kennedy, David O. “B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review.” Nutrients vol. 8,2 68. 27 Jan. 2016, doi:10.3390/nu8020068
[10] Mashayekh, Ameneh et al. “Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study.” Neuroradiology vol. 53,3 (2011): 185-91. doi:10.1007/s00234-010-0790-6
[11] Lou HC. Dopamine precursors and brain function in phenylalanine hydroxylasedeficiency. Acta Paediatr Suppl. 1994 Dec;407:86-8. Review. PubMed PMID: 7766968.
[12] Purves D, Augustine GJ, Fitzpatrick D, et al., editors. Neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Glutamate Receptors. Available from: https://www.ncbi.nlm.nih.gov/books/NBK10802/
[13] Yarotskyy V, Glushakov AV, Sumners C, Gravenstein N, Dennis DM, Seubert CN,Martynyuk AE. Differential modulation of glutamatergic transmission by3,5-dibromo-L-phenylalanine. Mol Pharmacol. 2005 May;67(5):1648-54. Epub 2005 Feb1. PubMed PMID: 15687225.
[14] Hasselmo, Michael E. “The role of acetylcholine in learning and memory.” Current opinion in neurobiology vol. 16,6 (2006): 710-5. doi:10.1016/j.conb.2006.09.002
[15] Kobayashi S, Iwamoto M, Kon K, Waki H, Ando S, Tanaka Y. Acetyl-L-carnitineimproves aged brain function. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S99-106.doi: 10.1111/j.1447-0594.2010.00595.x. PubMed PMID: 20590847.
[16] McGlade E, Agoston AM, DiMuzio J, Kizaki M, Nakazaki E, Kamiya T, Yurgelun-Todd D. The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. J Atten Disord. 2019 Jan;23(2):121-134. doi: 10.1177/1087054715593633. Epub 2015 Jul 15. PubMed PMID: 26179181.
[17] Food and Nutrition Sciences et al. "Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women" 2012, 3, 769-773. doi:10.4236/fns.2012.36103 Published Online June 2012
[18] Hellhammer, Juliane et al. “A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study.” Lipids in health and disease vol. 13 121. 31 Jul. 2014, doi:10.1186/1476-511X-13-121
[19] Roiser, Jonathan P et al. “The subjective and cognitive effects of acute phenylalanine and tyrosine depletion in patients recovered from depression.” Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 30,4 (2005): 775-85. doi:10.1038/sj.npp.1300659
[20] Jäger, Ralf et al. “The effect of phosphatidylserine on golf performance.” Journal of the International Society of Sports Nutrition vol. 4 23. 4 Dec. 2007, doi:10.1186/1550-2783-4-23
[21] Di Cesare Mannelli L, Vivoli E, Salvicchi A, Schiavone N, Koverech A, MessanoM, Nicolai R, Benatti P, Bartolini A, Ghelardini C. Antidepressant-like effect ofartemin in mice: a mechanism for acetyl-L-carnitine activity on depression.Psychopharmacology (Berl). 2011 Nov;218(2):347-56. doi:10.1007/s00213-011-2326-0. Epub 2011 May 18. PubMed PMID: 21590285.
[22] Aliev, Gjumrakch et al. “Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.” Journal of cellular and molecular medicine vol. 13,2 (2009): 320-33. doi:10.1111/j.1582-4934.2008.00324.x
[23] Salehi, Bahare et al. “Insights on the Use of α-Lipoic Acid for Therapeutic Purposes.” Biomolecules vol. 9,8 356. 9 Aug. 2019, doi:10.3390/biom9080356
[24] Wang, Huimin et al. “Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model.” Molecular medicine reports vol. 13,5 (2016): 4215-20. doi:10.3892/mmr.2016.5052
[25] Ma, Nan et al. “Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A.” Learning & memory (Cold Spring Harbor, N.Y.) vol. 16,6 367-70. 23 May. 2009, doi:10.1101/lm.1231009