DMAE has been reported to improve vigilance, attention, mood and energy while alleviating depression. [10]
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FULL INGREDIENT TRANSPARENCY
Say goodbye to brain fog and get focused.
Say goodbye to brain fog and get focused.
Acetylcholine, the "learning neurotransmitter", plays a key role in optimal cognitive functions specifically through improving attention-span, memory, and quick-thinking.[14]
Lightning-Fast Mental Accuracy & Speed
To optimize acetycholine levels, we've included ALCAR and Cognizin®.
ALCAR has been shown to boost memory, alertness, and problem-solving.[15] Cognizin® boosts acetylcholine levels in the brain. Studies have shown that Cognizin® improved focus, accuracy, specifically increasing the formation of brain membranes by 26% and brain energy utilization by 13.6%.[16] [17]
metaFOCUS can help you enter the elusive flow state while eradicating brain fog.
flow state noun
/ flō ˈstāt /
the brain’s optimal state of consciousness where an individual utilizes their skills to the utmost. In this state, individuals feel, perform, and focus at their best.
Key Compounds FOR Flow State
DMAE
Phosphatidylserine
Phosphatidylserine has been shown to reduce cortisol, the "stress hormone", eradicating the stress that can hinder you in achieving flow state.[11]
Dl-Phenylalanine
In flow, the brain releases key neurotransmitters which Phenylalanine are the building blocks for.
DL-Phenylalanine can also help reduce brain fog due to how it binds with glutamate AMPA receptors, improving communication between brain synapses.[12]
Acetyl-L-Carnitine
ALCAR has been shown to induce mental clarity and combat mental fatigue, supporting you in reaching flow.[13]
In a decade-long study conducted by McKinsey and Co. top executives found themselves 500% more productive when in flow.
FEATURED IN
Formulated with ingredients backed by clinical research.
8 NOOTROPIC COMPOUNDS
Artichoke Extract
300 mg (5% cynarins)
Luteolin, found in artichoke extract inhibits PDE4, which increases cAMP. Higher cAMP levels is correlated with improving learning, memory, and mood.[1]
FORSKOLIN
15 mg (20% forskolii)
Forskolin naturally increases cAMP levels synergizing with luteolin to strengthen neural synapses, also known as long-term potentiation improving cognitive function over time.[2]
Acetyl-l-carnitine
350 mg
ALCAR improves mitochondrial function and increase levels of noradrenaline, associated with focus and alertness. It has also been shown to be effective in reducing brain fog.[3]
SHARP-PS®
100 mg (PhosphatidylSerine)
PhosphatidylSerine has been shown to improve memory & increase concentration. It can also lower cortisol, reducing stress & intrusive thoughts.[4]
Artichoke Extract
400 mg (5% cynarins)
Luteolin, found in artichoke extract inhibits PDE4, which increases cAMP. Higher cAMP levels is correlated with improving learning, memory, and mood.[1]
FORSKOLIN
15 mg (20% forskolii)
Forskolin naturally increases cAMP levels synergizing with luteolin to strengthen neural synapses, also known as long-term potentiation improving cognition over time.[2]
Acetyl-l-carnitine
400 mg
ALCAR improves mitochondrial function and increase levels of noradrenaline, associated with focus and alertness. It has also been shown to be effective in reducing brain fog.[3]
SERinaid®
100 mg (PhosphatidylSerine)
PhosphatidylSerine has been shown to reduce cognitive decline, improve memory & reduce symptoms of ADHD. It can also lower cortisol, reducing anxiety & intrusive thoughts.[4]
GinkGO BILOBA
70 mg (24% glycosides)
DL-PHENYLALANINE
250 mg
Cognizin®
100 mg
Alpha-Lipoic Acid
100 mg (thiotic acid)
DMAE Bitartrate
100 mg
DMAE is a compound that has been shown to positively affect mood, enhance memory, and improve brain function.[5]
DL-PHENYLALANINE
240 mg
Phenylalanine is an amino acid that has been shown to produce improved attention-span, mood, and motivation.[6]
Cognizin®
100 mg
Cognizin® modulates levels of the acetylcholine neurotransmitter, which helps nerves to communicate, increase attention-span, and memory capacity.[7]
PQQ
10 mg
PQQ is a nootropic that has been shown to increase the number of mitochondria and improve their efficiency, leading to improved memory, sleep & energy.[8]
4 BRAIN VITAMINS
Vitamin b5
20 mg (pantothenic acid)
Essential for converting cholinergic nootropics into acetylcholine, the neurotransmitter responsible for focus, memory, and learning.[9]
Vitamin b6
5 mg (pyridoxal 5’-phosphate)
An essential vitamin which is required for the biosynthesis of several key neurotransmitters. We use P5P, one of the most bioactive forms of B6.[9]
Vitamin b9
1665 mcg (folic acid)
B9 is required for the synthesis of key neurotransmitters such as serotonin, playing an integral role in improving mood and cognitive function.[9]
Vitamin b12
100 mcg (methylcobalamin)
B12 is crucial for the synthesis of key neurotransmitters. Optimizing these neurotransmitters improve our mood, energy, and stress levels.[9]
Reduce stress to attain zen-like concentration.
Don’t let stress interrupt your workflow. metaFOCUS can help nullify mental stressors effectively and boost your productivity.
That’s why we’ve incorporated Sharp-PS® into our formula, a trademarked version of PhosphatidylSerine (PS), standardized to 60%. PS is a nootropic that plays a critical role in improving mental performance and reducing the body’s physiological response to stress by lowering cortisol levels.[18]
DL-Phenylalanine has been shown to enhance overall mood and improve ability to handle stress.[19]
PS Golfing Accuracy Study
PhosphatidylSerine supplementation significantly improved the ball flight accuracy of golfers as compared to the group that was given the placebo supplements.
PS Golfing Stress Levels Study
PhosphatidylSerine supplementation improved perceived stress levels during tee-off on a driving range, while perceived stress levels remained unchanged in the placebo group.
Customer Reviews
4.7
Based on 31 Reviews
Write a Review
Filter Reviews:
BH
08/18/2021
Ben H.
Awesome
Metafocus has been helping me get through the work day so it has been great.
CP
08/17/2021
Clayton P.
United StatesCLEAN FOCUS
No come down. Clean focus and energy.
JH
07/04/2021
Jack H.
Calming Focus
Calm level of focus but I do want it to give a stronger boost
CP
06/23/2021
Clayton P.
United Statesgreat
much better experience than prescriptions.
RK
06/22/2021
Ronald K.
Consistent
Liking how consistent my energy levels have been since I started taking these
References
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[2] Lepski, Guilherme et al. “cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.” Frontiers in cellular neuroscience vol. 7 155. 19 Sep. 2013, doi:10.3389/fncel.2013.00155
[3] Loots DT, Mienie LJ, Bergh JJ, Van der Schyf CJ. Acetyl-L-carnitine preventstotal body hydroxyl free radical and uric acid production induced by1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat. Life Sci. 2004Jul 23;75(10):1243-53. PubMed PMID: 15219812.
[4] Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015Jun;31(6):781-6. doi: 10.1016/j.nut.2014.10.014. Epub 2014 Nov 4. Review. PubMedPMID: 25933483.
[5] Mashayekh, Ameneh et al. “Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study.” Neuroradiology vol. 53,3 (2011): 185-91. doi:10.1007/s00234-010-0790-6
[6] Lou HC.D precursors and brain function in phenylalanine hydroxylasedeficiency. Acta Paediatr Suppl. 1994 Dec;407:86-8. Review. PubMed PMID: 7766968.
[7] Fioravanti, Mario, and Ann E Buckley. “Cognizin in the treatment of cognitive impairment.” Clinical interventions in aging vol. 1,3 (2006): 247-51. doi:10.2147/ciia.2006.1.3.247
[8] Packer, Lester, and Enrique Cadenas. “Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling.” Journal of clinical biochemistry and nutrition vol. 48,1 (2011): 26-32. doi:10.3164/jcbn.11-005FR
[9] Kennedy, David O. “B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review.” Nutrients vol. 8,2 68. 27 Jan. 2016, doi:10.3390/nu8020068
[10] Mashayekh, Ameneh et al. “Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study.” Neuroradiology vol. 53,3 (2011): 185-91. doi:10.1007/s00234-010-0790-6
[11] Lou HC. D precursors and brain function in phenylalanine hydroxylasedeficiency. Acta Paediatr Suppl. 1994 Dec;407:86-8. Review. PubMed PMID: 7766968.
[12] Purves D, Augustine GJ, Fitzpatrick D, et al., editors. Neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Glutamate Receptors. Available from: https://www.ncbi.nlm.nih.gov/books/NBK10802/
[13] Yarotskyy V, Glushakov AV, Sumners C, Gravenstein N, Dennis DM, Seubert CN,Martynyuk AE. Differential modulation of glutamatergic transmission by3,5-dibromo-L-phenylalanine. Mol Pharmacol. 2005 May;67(5):1648-54. Epub 2005 Feb1. PubMed PMID: 15687225.
[14] Hasselmo, Michael E. “The role of acetylcholine in learning and memory.” Current opinion in neurobiology vol. 16,6 (2006): 710-5. doi:10.1016/j.conb.2006.09.002
[15] Kobayashi S, Iwamoto M, Kon K, Waki H, Ando S, Tanaka Y. Acetyl-L-carnitineimproves aged brain function. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S99-106.doi: 10.1111/j.1447-0594.2010.00595.x. PubMed PMID: 20590847.
[16] McGlade E, Agoston AM, DiMuzio J, Kizaki M, Nakazaki E, Kamiya T, Yurgelun-Todd D. The Effect of Choline Supplementation on Motor Speed and Attention in Adolescent Males. J Atten Disord. 2019 Jan;23(2):121-134. doi: 10.1177/1087054715593633. Epub 2015 Jul 15. PubMed PMID: 26179181.
[17] Food and Nutrition Sciences et al. "Improved Attentional Performance Following Choline Administration in Healthy Adult Women" 2012, 3, 769-773. doi:10.4236/fns.2012.36103 Published Online June 2012
[18] Hellhammer, Juliane et al. “A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study.” Lipids in health and disease vol. 13 121. 31 Jul. 2014, doi:10.1186/1476-511X-13-121
[19] Roiser, Jonathan P et al. “The subjective and cognitive effects of acute phenylalanine and tyrosine depletion in patients recovered from depression.” Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 30,4 (2005): 775-85. doi:10.1038/sj.npp.1300659
[20] Jäger, Ralf et al. “The effect of phosphatidylserine on golf performance.” Journal of the International Society of Sports Nutrition vol. 4 23. 4 Dec. 2007, doi:10.1186/1550-2783-4-23
[21] Di Cesare Mannelli L, Vivoli E, Salvicchi A, Schiavone N, Koverech A, MessanoM, Nicolai R, Benatti P, Bartolini A, Ghelardini C. Antidepressant-like effect ofartemin in mice: a mechanism for acetyl-L-carnitine activity on depression.Psychopharmacology (Berl). 2011 Nov;218(2):347-56. doi:10.1007/s00213-011-2326-0. Epub 2011 May 18. PubMed PMID: 21590285.
[22] Aliev, Gjumrakch et al. “Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.” Journal of cellular and molecular medicine vol. 13,2 (2009): 320-33. doi:10.1111/j.1582-4934.2008.00324.x
[23] Salehi, Bahare et al. “Insights on the Use of α-Lipoic Acid for Therapeutic Purposes.” Biomolecules vol. 9,8 356. 9 Aug. 2019, doi:10.3390/biom9080356
[24] Wang, Huimin et al. “Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model.” Molecular medicine reports vol. 13,5 (2016): 4215-20. doi:10.3892/mmr.2016.5052
[25] Ma, Nan et al. “Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A.” Learning & memory (Cold Spring Harbor, N.Y.) vol. 16,6 367-70. 23 May. 2009, doi:10.1101/lm.1231009